Growth-related oncogene ? induction of apoptosis in osteoarthritis chondrocytes
نویسندگان
چکیده
منابع مشابه
Hydroxytyrosol Prevents Increase of Osteoarthritis Markers in Human Chondrocytes Treated with Hydrogen Peroxide or Growth-Related Oncogene α
Hydroxytyrosol (HT), a phenolic compound mainly derived from olives, has been proposed as a nutraceutical useful in prevention or treatment of degenerative diseases. In the present study we have evaluated the ability of HT to counteract the appearance of osteoarthritis (OA) features in human chondrocytes. Pre-treatment of monolayer cultures of chondrocytes with HT was effective in preventing ac...
متن کاملTargeted deletion of Atg5 in chondrocytes promotes age-related osteoarthritis
OBJECTIVES It has been suggested that the lysosomal recycling process called macro-autophagy plays a role in osteoarthritis development. We thus decided to genetically ablate the autophagy-indispensable Atg5 gene specifically in chondrocytes and analyse the development of osteoarthritis upon aging and in a post-traumatic model. METHODS Mice lacking the Atg5 gene in their chondrocytes (Atg5cKO...
متن کاملAutophagy modulates osteoarthritis-related gene expression in human chondrocytes.
OBJECTIVE Autophagy, an evolutionarily conserved process for the bulk degradation of cytoplasmic components, serves as a cell survival mechanism. The purpose of this study was to elucidate the role of autophagy in human chondrocytes and pathophysiology of osteoarthritis (OA). METHODS Autophagy in articular cartilage and primary chondrocytes was assessed using antibodies for the autophagy mark...
متن کاملApoptosis and proliferation of growth plate chondrocytes in rabbits.
The growth plates of the femoral head of Japanese white rabbits aged 5, 10, 15 and 20 weeks were stained for apoptotic and proliferating chondrocytes using the TUNEL and PCNA antibody staining techniques. Both TUNEL- and PCNA-positive chondrocytes were detected in all of the specimens. The positive ratios of both stainings were calculated for the whole plate and for the resting, proliferating a...
متن کاملInduction of nerve growth factor expression and release by mechanical and inflammatory stimuli in chondrocytes: possible involvement in osteoarthritis pain
INTRODUCTION Nerve growth factor (NGF) level is increased in osteoarthritis (OA) joints and is involved in pain associated with OA. Stimuli responsible for NGF stimulation in chondrocytes are unknown. We investigated whether mechanical stress and proinflammatory cytokines may influence NGF synthesis by chondrocytes. METHODS Primary cultures of human OA chondrocytes, newborn mouse articular ch...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 2002
ISSN: 0004-3591,1529-0131
DOI: 10.1002/art.10650